Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.
Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.
While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.
In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.
Read More
8
Zinc, cholesterol, and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
We delved into the intriguing relationship between trace minerals, specifically zinc, and high cholesterol levels related to coronary artery disease (CAD). Our study focused on middle-aged and older adults living in Shika town, Japan, and involved 895 residents, carefully excluding those with a genetic predisposition to high cholesterol.
By analyzing their dietary habits through a questionnaire, we found notable interactions between dyslipidaemia, or high cholesterol, and zinc intake. Our detailed examination revealed that a lower intake of zinc, alongside other trace minerals like copper and manganese, correlated with a higher risk of CAD in individuals with dyslipidaemia.
What we learned was striking: zinc, copper, and manganese emerged as significant factors linked to CAD, especially for those struggling with dyslipidaemia. The odds ratios suggested that sufficient zinc intake might play a protective role against CAD in these individuals. These findings illuminate the potential importance of trace minerals in maintaining heart health, particularly for those facing challenges with cholesterol levels. However, further research is essential to confirm these early observations and better understand the nature of these relationships.
Read More
8
Zinc's variable impact on cholesterol
Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus.
We conducted a study to explore the effects of zinc supplementation on cholesterol levels in newly diagnosed patients with Type 2 diabetes. In this randomized, placebo-controlled trial, 80 patients received either zinc (50 mg/day) or a placebo alongside their regular diabetes medication, metformin.
Over a year, we measured important health indicators such as blood glucose levels and cholesterol profiles. Our findings showed that patients who took zinc saw reductions in low-density lipoprotein (LDL) cholesterol and triglycerides, marking some positive outcomes for cholesterol management. Specifically, LDL cholesterol dropped by an average of 25.06 mg/dL, and triglycerides decreased by about 22.2 mg/dL.
However, we also noted that zinc supplementation did not result in any significant changes in high-density lipoprotein (HDL) cholesterol. This means while zinc may help lower some types of "bad" cholesterol, it doesn’t seem to improve the "good" cholesterol levels. Overall, while zinc could be a useful addition to diabetes care, its effects on cholesterol levels were inconclusive, highlighting the need for further investigation.
Read More
Most Useful Reviews
9
Improved health indices.
10 people found this helpful
After giving birth, I encountered various deficiencies. Within a month of taking this zinc picolinate, all my indicators improved, and my hair and skin condition is notably better! I am thrilled! Solgar provides a perfect 22 mg dosage that meets my daily requirements. My whole family uses it during colds, and we maintain our health with zinc, vitamin C, and D3.
Read More
9
Reliable supplement choice.
9 people found this helpful
As usual, Solgar provides high-quality supplements that I can trust. I take the Zinc Picolinate daily due to being on birth control pills, which deplete certain nutrients. This zinc has greatly improved my skin.
Read More
9
Fights colds effectively.
1 people found this helpful
I adore this zinc picolinate supplement. It is the most bioavailable zinc form and has significantly boosted my immunity and overall health. During winter, I take one capsule daily; if I feel unwell, I take 75 mg for a short duration, effectively combatting colds. Just remember not to overdo it, as excessive zinc can upset your stomach. Follow dosage guidelines and you'll be fine. I highly recommend it.
Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.
Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.
While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.
In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.
Read More
8
Zinc's variable impact on cholesterol
Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus.
We conducted a study to explore the effects of zinc supplementation on cholesterol levels in newly diagnosed patients with Type 2 diabetes. In this randomized, placebo-controlled trial, 80 patients received either zinc (50 mg/day) or a placebo alongside their regular diabetes medication, metformin.
Over a year, we measured important health indicators such as blood glucose levels and cholesterol profiles. Our findings showed that patients who took zinc saw reductions in low-density lipoprotein (LDL) cholesterol and triglycerides, marking some positive outcomes for cholesterol management. Specifically, LDL cholesterol dropped by an average of 25.06 mg/dL, and triglycerides decreased by about 22.2 mg/dL.
However, we also noted that zinc supplementation did not result in any significant changes in high-density lipoprotein (HDL) cholesterol. This means while zinc may help lower some types of "bad" cholesterol, it doesn’t seem to improve the "good" cholesterol levels. Overall, while zinc could be a useful addition to diabetes care, its effects on cholesterol levels were inconclusive, highlighting the need for further investigation.
Read More
8
Zinc, cholesterol, and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
We delved into the intriguing relationship between trace minerals, specifically zinc, and high cholesterol levels related to coronary artery disease (CAD). Our study focused on middle-aged and older adults living in Shika town, Japan, and involved 895 residents, carefully excluding those with a genetic predisposition to high cholesterol.
By analyzing their dietary habits through a questionnaire, we found notable interactions between dyslipidaemia, or high cholesterol, and zinc intake. Our detailed examination revealed that a lower intake of zinc, alongside other trace minerals like copper and manganese, correlated with a higher risk of CAD in individuals with dyslipidaemia.
What we learned was striking: zinc, copper, and manganese emerged as significant factors linked to CAD, especially for those struggling with dyslipidaemia. The odds ratios suggested that sufficient zinc intake might play a protective role against CAD in these individuals. These findings illuminate the potential importance of trace minerals in maintaining heart health, particularly for those facing challenges with cholesterol levels. However, further research is essential to confirm these early observations and better understand the nature of these relationships.
Read More
8
Study on zinc and cholesterol outcomes
Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.
We conducted a randomized clinical trial involving 75 patients with type 2 diabetes to explore the effects of a nutraceutical combination containing myo-inositol, d-chiro-inositol, α-lactalbumin, Gymnema sylvestre, and zinc on cholesterol levels.
While the overall results showed no significant improvement in glucose levels among the groups, we did observe reductions in total cholesterol and LDL levels in the supplement group after three months. Interestingly, a subgroup that did not change their diabetes medication displayed even greater improvements in cholesterol levels—suggesting potential benefits from the supplement combination.
However, it's important to note that the study did not assess the specific impact of zinc alone on cholesterol. Therefore, while we found promising results for the combination used, we cannot definitively attribute any cholesterol-lowering effects directly to zinc in isolation.
Read More
7
Zinc's role in cholesterol management
The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats.
In our study, we explored how zinc supplementation might influence cholesterol levels in a controlled experiment with male Wistar rats. We divided the 48 rats into three diet groups: those on a high-fat diet, a caloric restriction diet, and a normal diet. The high-fat diet group was further split into four categories, where some received zinc, selenium, or a combination of both, while one group served as the control.
After eight weeks of monitoring, we conducted biochemical tests to assess key factors such as triglyceride levels, cholesterol, and blood sugar. Although zinc has potential benefits, our findings suggest that its supplementation did not significantly lower cholesterol levels when compared to the control group on a high-fat diet. Despite the lack of notable changes, this research indicates that more studies are needed to understand zinc's role in managing high cholesterol, especially when combined with other supplements.
We came to realize that while zinc and selenium have their merits, they might not directly target high cholesterol levels effectively within this specific model. The complexity of obesity-related conditions requires a deeper investigation into individual nutrient effects and their interactions.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8
All Reviews
Positive Reviews
Negative Reviews
9
Improved health indices.
10 people found this helpful
After giving birth, I encountered various deficiencies. Within a month of taking this zinc picolinate, all my indicators improved, and my hair and skin condition is notably better! I am thrilled! Solgar provides a perfect 22 mg dosage that meets my daily requirements. My whole family uses it during colds, and we maintain our health with zinc, vitamin C, and D3.
Read More
9
Reliable supplement choice.
9 people found this helpful
As usual, Solgar provides high-quality supplements that I can trust. I take the Zinc Picolinate daily due to being on birth control pills, which deplete certain nutrients. This zinc has greatly improved my skin.
Read More
9
Fights colds effectively.
1 people found this helpful
I adore this zinc picolinate supplement. It is the most bioavailable zinc form and has significantly boosted my immunity and overall health. During winter, I take one capsule daily; if I feel unwell, I take 75 mg for a short duration, effectively combatting colds. Just remember not to overdo it, as excessive zinc can upset your stomach. Follow dosage guidelines and you'll be fine. I highly recommend it.
Read More
7.5
Hair loss improvement.
1 people found this helpful
Great! I completed the course of Solgar zinc some time ago, and I must share my impressions. Zinc is essential for keeping skin and hair healthy. It enhances skin condition by regulating sebaceous glands, bolsters the immune system, prevents inflammation, and supports healing. I particularly needed it as I was experiencing significant hair loss. After several weeks, without much faith, I noticed my hair falling out less and my skin appearing healthier. I plan to continue taking it.
Read More
7.5
Significant skin improvement.
9 people found this helpful
This zinc picolinate 22 mg is superb! My doctor advised this form for its optimal absorption. I took two tablets daily for two months, then reduced to one per day. The small, round tablets are easy to swallow. I noticed significantly fewer rashes, my skin elasticity improved, hair grew better, and nails became stronger. Always trust the quality from Solgar.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc plays a crucial role in various bodily functions, including immune system support and wound healing, but its effect on cholesterol levels is not well-established. Some studies suggest that zinc may have a modest impact on lipid profiles, including potentially lowering levels of total cholesterol and triglycerides. However, these findings are not conclusive enough to recommend zinc supplementation as a primary treatment for high cholesterol.
If you're considering zinc supplements for cholesterol management, it's essential to consult with a healthcare professional first. They can provide personalized guidance based on your individual health needs and suggest more established lifestyle changes, such as a balanced diet and regular exercise, which are proven strategies for managing cholesterol levels effectively. Remember that while supplements can support health in specific areas, they should not replace conventional treatment methods prescribed by your doctor.
Based on user reviews, the time it generally takes to see results from taking zinc picolinate varies, but many users report noticeable improvements within a few weeks to a couple of months. For instance, one reviewer mentioned that after several weeks of use, they noticed fewer hair fall and healthier skin, which suggest that a timeline of 4 to 8 weeks may yield positive changes for some individuals Read Review. Another user took the supplement daily for two months before switching to a lower dosage, and during that time, they observed significant improvements in their skin and hair health Read Review.
It’s important to note that results may vary depending on factors like individual health conditions and consistency in taking the supplement. Some users have expressed that immediate effects on energy levels and immune support were noticeable within a month Read Review. As with any supplement, patients should consult their healthcare provider for personalized advice and monitoring, especially for specific conditions like high cholesterol.
Zinc supplementation shows promising potential for managing cholesterol levels, particularly in individuals with Type 2 diabetes. A study involving 1,357 participants found that zinc led to reductions in triglycerides, total cholesterol, and low-density lipoprotein (LDL) cholesterol, with decreases of 17.41 mg/dL, 19.60 mg/dL, and 8.80 mg/dL, respectively. Notably, there was also an increase in high-density lipoprotein (HDL) cholesterol of about 4.82 mg/dL, suggesting that zinc may positively influence overall lipid profiles in those with diabetes [4].
Additionally, research focusing on zinc's interactions with other minerals has indicated that adequate zinc intake may not only help lower "bad" cholesterol but could also be linked to a reduced risk of coronary artery disease among individuals suffering from dyslipidaemia [2]. However, it's important to note that there are some inconsistencies in findings; in some studies involving animal models, zinc's impact on cholesterol was not significant when compared to control subjects [3]. While the research indicates potential benefits of zinc in cholesterol management, further investigation is needed to fully understand its effects and to clarify its effectiveness in isolation compared to combination approaches [5].
Based on user reviews, many individuals have reported significant improvements in various symptoms after incorporating zinc picolinate into their daily routine. A number of users have noted enhancements in skin health, with mentions of clearer complexions, reduced rashes, and overall better skin elasticity after regular use. One reviewer highlighted that after a month of taking the supplement, all their health indicators improved, alongside a noticeable difference in their hair and skin condition Read Review. Another user observed significantly fewer breakouts and a marked improvement in their skin after combining it with a healthier diet Read Review.
In addition to benefits for skin, several users have reported reduced hair loss and improved hair health, with one individual sharing their experience of less hair fall and healthier growth after several weeks of use Read Review. Improving overall immunity was another common theme; users have mentioned better resilience against colds and increased energy levels during winter months Read Review. While these anecdotal experiences suggest positive outcomes, it is essential to remember that individual results can vary greatly, and users should approach supplements with careful consideration and consultation with healthcare providers.
Based on user reviews, several individuals reported positive experiences when combining zinc picolinate with other supplements to manage their health, particularly in areas like skin condition and immune support. Many users mentioned pairing zinc with vitamin C and vitamin D3, noting enhanced benefits for their immune system and overall wellness. For instance, one reviewer highlighted that their family maintains health during colds by using zinc in conjunction with these vitamins Read Review. Additionally, another user specifically combined zinc with vitamin A and probiotics to address skin issues, reporting noticeable improvements in skin health Read Review.
However, it's worth noting that while many users experienced benefits, there were warnings about potential side effects. One user expressed concern about hair loss, suggesting that while zinc can be beneficial, it may not be suitable for everyone, particularly if taken in high doses or without proper dietary balance Read Review. As always, consulting healthcare providers for personalized supplementation advice is recommended. This ensures that users can safely combine supplements while addressing their specific health issues.
Based on the available research, the optimal dose of zinc for treating high cholesterol appears to be around 50 mg per day for individuals with conditions such as type 2 diabetes. In one study, patients who received this dosage alongside their usual metformin treatment experienced significant reductions in low-density lipoprotein (LDL) cholesterol and triglycerides. Specifically, LDL cholesterol decreased by an average of 25.06 mg/dL, and triglycerides dropped by roughly 22.2 mg/dL, indicating a positive impact on cholesterol management [1].
However, zinc supplementation may not significantly influence high-density lipoprotein (HDL) cholesterol levels, which are crucial for cardiovascular health. Moreover, another synthesis of various studies highlighted that even lower doses might provide some benefits, showcasing reductions in total cholesterol, LDL-C, and triglycerides while also noting an increase in HDL-C [4]. While these findings suggest zinc could be a beneficial adjunct therapy in cholesterol management, further studies are essential to validate these results and explore optimal dosages corresponding to different health conditions. As always, individuals should consult healthcare professionals before starting any supplementation regimen.
7.5
Hair loss improvement.
1 people found this helpful
Great! I completed the course of Solgar zinc some time ago, and I must share my impressions. Zinc is essential for keeping skin and hair healthy. It enhances skin condition by regulating sebaceous glands, bolsters the immune system, prevents inflammation, and supports healing. I particularly needed it as I was experiencing significant hair loss. After several weeks, without much faith, I noticed my hair falling out less and my skin appearing healthier. I plan to continue taking it.
7.5
Significant skin improvement.
9 people found this helpful
This zinc picolinate 22 mg is superb! My doctor advised this form for its optimal absorption. I took two tablets daily for two months, then reduced to one per day. The small, round tablets are easy to swallow. I noticed significantly fewer rashes, my skin elasticity improved, hair grew better, and nails became stronger. Always trust the quality from Solgar.
7.5
Boosted immunity noted.
1 people found this helpful
I took this product for a month alongside other vitamins and felt much better. I now have high energy levels. Zinc stimulates the immune system, so I use it during colds, with my doctor often prescribing a double dose when ill. It works wonders! Solgar’s products are of high quality. I take it on an empty stomach, but if it causes nausea, I recommend taking it with breakfast.
9
Improved health indices.
10 people found this helpful
After giving birth, I encountered various deficiencies. Within a month of taking this zinc picolinate, all my indicators improved, and my hair and skin condition is notably better! I am thrilled! Solgar provides a perfect 22 mg dosage that meets my daily requirements. My whole family uses it during colds, and we maintain our health with zinc, vitamin C, and D3.
7.5
Fewer rashes observed.
21 people found this helpful
My daughter has teenage rashes, so we took zinc picolinate, opting for Solgar due to the high quality of their vitamins and our trust in the brand. We take it at lunch alongside vitamin A and a probiotic while improving her diet by removing sweets. We see fewer rashes, and when they do appear, they are minor and heal quickly. I highly recommend this product. If this review was helpful, please like!
9
Fights colds effectively.
1 people found this helpful
I adore this zinc picolinate supplement. It is the most bioavailable zinc form and has significantly boosted my immunity and overall health. During winter, I take one capsule daily; if I feel unwell, I take 75 mg for a short duration, effectively combatting colds. Just remember not to overdo it, as excessive zinc can upset your stomach. Follow dosage guidelines and you'll be fine. I highly recommend it.
0
Negative hair effects
1 people found this helpful
Be cautious! My hair began falling out due to this zinc—everywhere, from my legs to my head. My mother experienced the same issue. While there may be some good skin benefits, the price is rather exorbitant, considering the hair loss.
9
Zinc improves cholesterol levels
Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.
Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.
While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.
In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.
8
Zinc, cholesterol, and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
We delved into the intriguing relationship between trace minerals, specifically zinc, and high cholesterol levels related to coronary artery disease (CAD). Our study focused on middle-aged and older adults living in Shika town, Japan, and involved 895 residents, carefully excluding those with a genetic predisposition to high cholesterol.
By analyzing their dietary habits through a questionnaire, we found notable interactions between dyslipidaemia, or high cholesterol, and zinc intake. Our detailed examination revealed that a lower intake of zinc, alongside other trace minerals like copper and manganese, correlated with a higher risk of CAD in individuals with dyslipidaemia.
What we learned was striking: zinc, copper, and manganese emerged as significant factors linked to CAD, especially for those struggling with dyslipidaemia. The odds ratios suggested that sufficient zinc intake might play a protective role against CAD in these individuals. These findings illuminate the potential importance of trace minerals in maintaining heart health, particularly for those facing challenges with cholesterol levels. However, further research is essential to confirm these early observations and better understand the nature of these relationships.
7
Zinc's role in cholesterol management
The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats.
In our study, we explored how zinc supplementation might influence cholesterol levels in a controlled experiment with male Wistar rats. We divided the 48 rats into three diet groups: those on a high-fat diet, a caloric restriction diet, and a normal diet. The high-fat diet group was further split into four categories, where some received zinc, selenium, or a combination of both, while one group served as the control.
After eight weeks of monitoring, we conducted biochemical tests to assess key factors such as triglyceride levels, cholesterol, and blood sugar. Although zinc has potential benefits, our findings suggest that its supplementation did not significantly lower cholesterol levels when compared to the control group on a high-fat diet. Despite the lack of notable changes, this research indicates that more studies are needed to understand zinc's role in managing high cholesterol, especially when combined with other supplements.
We came to realize that while zinc and selenium have their merits, they might not directly target high cholesterol levels effectively within this specific model. The complexity of obesity-related conditions requires a deeper investigation into individual nutrient effects and their interactions.
8
Study on zinc and cholesterol outcomes
Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.
We conducted a randomized clinical trial involving 75 patients with type 2 diabetes to explore the effects of a nutraceutical combination containing myo-inositol, d-chiro-inositol, α-lactalbumin, Gymnema sylvestre, and zinc on cholesterol levels.
While the overall results showed no significant improvement in glucose levels among the groups, we did observe reductions in total cholesterol and LDL levels in the supplement group after three months. Interestingly, a subgroup that did not change their diabetes medication displayed even greater improvements in cholesterol levels—suggesting potential benefits from the supplement combination.
However, it's important to note that the study did not assess the specific impact of zinc alone on cholesterol. Therefore, while we found promising results for the combination used, we cannot definitively attribute any cholesterol-lowering effects directly to zinc in isolation.
8
Zinc's variable impact on cholesterol
Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus.
We conducted a study to explore the effects of zinc supplementation on cholesterol levels in newly diagnosed patients with Type 2 diabetes. In this randomized, placebo-controlled trial, 80 patients received either zinc (50 mg/day) or a placebo alongside their regular diabetes medication, metformin.
Over a year, we measured important health indicators such as blood glucose levels and cholesterol profiles. Our findings showed that patients who took zinc saw reductions in low-density lipoprotein (LDL) cholesterol and triglycerides, marking some positive outcomes for cholesterol management. Specifically, LDL cholesterol dropped by an average of 25.06 mg/dL, and triglycerides decreased by about 22.2 mg/dL.
However, we also noted that zinc supplementation did not result in any significant changes in high-density lipoprotein (HDL) cholesterol. This means while zinc may help lower some types of "bad" cholesterol, it doesn’t seem to improve the "good" cholesterol levels. Overall, while zinc could be a useful addition to diabetes care, its effects on cholesterol levels were inconclusive, highlighting the need for further investigation.
References
Chhina GS, Chhabra A, Luthra SR, Khattar S, Singh P, et al. Effect of Zinc Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus. Cureus. 2024;16:e69180. doi:10.7759/cureus.69180
Kimura K, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, et al. Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study. J Nutr Sci. 2024;13:e45. doi:10.1017/jns.2024.26
Hasani M, Monfared V, Aleebrahim-Dehkordi E, Jafari A, Agh F, et al. The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats. Curr Mol Med. 2024;24:1307. doi:10.2174/0115665240268180231113045836
Khajeh M, Hassanizadeh S, Pourteymour Fard Tabrizi F, Hassanizadeh R, Vajdi M, et al. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. Biol Trace Elem Res. 2024;202:4877. doi:10.1007/s12011-024-04059-x
Nani A, Bertuzzi F, Meneghini E, Mion E, Pintaudi B. Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. J Clin Med. 2023;12. doi:10.3390/jcm12247650